Effect of Centella asiatica Linn on physical and chemical factors induced gastric ulceration and secretion in rats.
Sairam K, Rao CV, Goel RK.
Indian J Exp Biol 2001 Feb;39(2):137-42
Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221005, India.
The present study was conducted to evaluate the possible anti-ulcerogenic activity of fresh juice of C. asiatica (CAJ) against ethanol-, aspirin-, cold-restraint stress- and pyloric ligation induced gastric ulcers in rats. CAJ showed little or no effect on offensive acid-pepsin secretion. However, at 600 mg/kg CAJ significantly increased gastric juice mucin secretion and increased the mucosal cell glycoproteins signifying increase in cellular mucus. It also decreased cell shedding indicating fortification of mucosal barrier. Thus, the ulcer protective effect of CAJ may be due to strengthening of the mucosal defensive factors.