http://jama.jamanetwork.com/article.aspx?articleid=197077

 

Guggulipid for the Treatment of Hypercholesterolemia

A Randomized Controlled Trial

Philippe O. Szapary, MD; Megan L. Wolfe, BS; LeAnne T. Bloedon, MS, RD; Andrew J. Cucchiara, PhD; Ara H. DerMarderosian, PhD; Michael D. Cirigliano, MD; Daniel J. Rader, MD

JAMA. 2003;290:765-772.

ABSTRACT

Conclusions  Despite plausible mechanisms of action, guggulipid did not appear to improve levels of serum cholesterol over the short term in this population of adults with hypercholesterolemia, and might in fact raise levels of LDL-C. Guggulipid also appeared to cause a dermatologic hypersensitivity reaction in some patients.