Antineoplastic Properties ofMaharishi Arnrit Kalash [MAK-5], An Ayurvedic Food Supplement, Against
7,12-Dimethylben2(a)anthracene-lnduced Mammary Tumors in Rats
Journal of Research and Education in Indian Medicine, Vol. 10, No. 3, pp. 1-8, July-September 1991
Hari M. Sharma,* Chandradhar Dwivedi,** Bryan C. Satter,** and Hussein Abou-lssa.*
* College of Medicine, The Ohio State University, Columbus, OH 43210
**College of Pharmacy, South Dakota State University, Brookings, SD 37007
The herbal mixture Maharishi Arnrit Kalash-5 (MAK-5) was tested for antineoplastic properties against 7,12- dimethylbenz(a)anthracene (DMBA)-induced
mammary tumors in rats. The 0.2% (w/w) MAK-5-supplemented diet protected against DMBA-induced carcinogenesis during the promotion phase. MAK-5 provided up to 62.5% protection (p<0.03) during the promotion phase of carcinogenesis. Also, a MAK-5-supplemented diet fed for four weeks to control rats which had developed mammary tumors, decreased tumor size in 60% of these rats.