Cancer Research

5.  Title

Chemopreventive Activity of Maharishi Arnrit Kalash [MAK-4 and MAK-5] and Related Agents in Rat Tracheal Epithelial and Human Tumor Cells

Publication

Proceedings of the American Association for Cancer Research, Vol. 32, p. 128, 1991 (Abstract).

Authors

J.T. Arnold,* B.P. Wilkinson,* E.A. Korytynski,* and V.E. Steele.**

Conducted at

* ManTech Environmental Technology, Inc., RTP, NC 27709

**National Cancer Institute, Bethesda, MD 20892

Summary

...results suggest that MAK-4 and MAK-5 inhibit processes of neoplastic transformation. Compounds tested in these assays that are similar to the ingredients in MAK-4 and MAK-5 also show chemopreventive activity. These include curcumin, ferulic acid, catechin, bioflavonoids, retinoic acid, ascorbyl palmitate, and glycyrrhetinic acid.

6.  Title

Antioxidant Adjuvant Therapy Using Natural Herbal Mixtures [MAK-4 and MAK-3] During Intensive Chemotherapy: Reduction in Toxicity. A Prospective Study of 62 Patients

Publication

Rao, R.S., Deo, M.G., and Sanghvi, L.D. (eds). Proceedings of the XVI International Cancer Congress. Bologna, Italy: Monduzzi Editore, 1994: pp. 3099-3102.

Authors

N.C. Misra,* H.M. Sharma,** A. Chaturvedi,* Ramakant,* S. Srivastav,* V. Devi,* P. Kakkar,t Vishwanathan.t S.M. Natu,* andJ. Bogra*

Conducted at

* K.G. Medical College, Lucknow, India **The Ohio State University, Columbus, OH  &  Indian   Toxicology  Research   Centre,   Lucknow,   India

Summary

MAK-4 and MAK-5 supplementation was effective in reducing toxic chemotherapy side effects in patients undergoing intensive chemotherapy. Patients receiving the supplements experienced reduced hematologic toxicity, vomiting, and diarrhea, and improved sleep, weight, and well-being.